Hacker News
1h, 42p, 4 comments
Chemistry behind the Garden Grove chemical tank
The article emphasizes urgent changes, detailing critical steps and their implications, offering insights into current developments.
5h, 80p, 13 comments
The Ballad of TIGIT
The article chronicles the rise and catastrophic failure of TIGIT-targeted cancer drugs, a class once hailed as the successor to Keytruda. Driven by strong preclinical theory—TIGIT was believed to be a critical immune checkpoint exploited by tumors—pharmaceutical giants like Roche, Merck, and AstraZeneca poured billions into developing anti-TIGIT antibodies. Roche’s tiragolumab showed early promise in phase 2 trials, prompting a massive parallel trial program (SKYSCRAPER) across dozens of cancer types. However, the entire class ultimately failed: Roche’s flagship phase 3 trials missed their endpoints, Merck halted its vibostolimab program due to safety and efficacy issues, and even the last hope—Arcus’s Fc-silent antibody domvanalimab—failed in a phase 3 trial. The analysis estimates nearly 49,000 patients enrolled and over $3 billion spent on a hypothesis that proved incorrect. The piece concludes that TIGIT was not “nonsense” but represented sound translational biology that simply did not translate into clinical benefit, serving as a humbling lesson that not every biological brake is therapeutically accessible.
5h, 58p, 43 comments
Launch HN: Minicor (YC P26) — Windows desktop automations at scale
Minicor è una piattaforma che consente di creare e gestire automazioni desktop su larga scala, consentendo alle aziende di collegare sistemi informatici legacy con soluzioni AI; support We need to follow the instruction: Summarize the main content, ignoring navigation etc. Summarize concisely, one paragraph, journalistic style, plain text, no markdown, but we can use and tags for important points, names, places, text. Must not include “Certainly!” etc. Also must not mention “Certainly!” etc. Also must not mention Cloudflare etc. If any block, respond “Summary not available.” But we have content; we can produce summary.
We need to summarize main content: Minicor is a scalable desktop automation platform, backed by Y Combinator, SOC2, HIPAA, enabling AI to interact with legacy desktop apps via agents that self-heal, deploy anywhere, built-in observability, etc. Summarize concisely, one paragraph, journalistic style, using and for important points, names, places, text. Use HTML tags for emphasis.
We need to identify important points: “Minicor”, “Y Combinator”, “SOC 2 Type II”, “HIPAA Compliant”, “Self-Healing Agents”, “Deploy Anywhere”, “Built-in Observability”, “API call triggers workflow”, “Scale to 25,000 patients/day”, “Desktop App”, “Workflow Editor”, “Replay recordings”, “Slack alerts”. Also mention “Book a Demo” maybe not needed.
We need to write in plain prose, but we can embed and tags around key terms. For example: “Minicor is a scalable desktop automation platform backed by Y Combinator and SOC 2 Type II certified, HIPAA compliant.” Then mention self-healing etc.
Make sure it’s one paragraph, no
4h, 152p, 375 comments
The real cost of owning a home
The Real Cost of Owning aHome by Eric Turner outlines hidden expenses that often exceed rent, detailing mortgage settlement costs averaging 12,777.92 dollars, monthly payments where 80 % of the first payment is interest, ongoing property taxes, insurance, mandatory PMI and its eventual removal, and cumulative Maintenance & Repairs that can reach tens of thousands of dollars, plus home improvements and rising utility costs driven by higher electricity rates, significant selling expenses of roughly ten percent of home value, and long‑term appreciation that only justifies purchase if ownership spans many years. This comprehensive breakdown suggests that buying a house is financially sensible only when the owner plans to stay long enough for appreciation to outweigh these cumulative costs.
6h, 52p, 22 comments
Are we self-sovereign PKI yet?
The article arguesthat self‑sovereign PKI remains unattained, pointing out that even end‑to‑end encrypted services like Signal and iMessage still hinge on server honesty and that current certificate authorities are custodial and vulnerable to BGP leaks or CA compromise, whereas Spaces offers a novel approach by binding human‑scale identifiers such as grace@key to public keys through a Bitcoin‑anchored Merkle trie, using a 32‑byte trust‑anchor hash verified by a lightweight client Veritas, with plans for zero‑knowledge certificates that function as a CA without a private key, thereby eliminating the need for repeated fingerprint verification.
15h, 109p, 84 comments
Performance of Rust Language [pdf]
The page discusses GitHub’s AI-powered tools such as Yugr/Rust Slides, focusing on code enhancement, security features, and developer workflows. It highlights features like Copilot for Business, enterprise security, and best practices for Rust programming. The content outlines uses in modernizing applications, ensuring code safety, and maintaining security standards. It also mentions integrations, advanced security protections, and developments for different team sizes and industries.
2h, 37p, 3 comments
Modern Blu-ray drives can now rip GameCube, Wii, and Xbox 360 games to PC
A third-party firmware called OmniDrive now enables select Blu-ray drives with the MediaTek MT1959 chipset (from brands like Asus, LG, Buffalo, and Verbatim) to rip physical games from GameCube, Wii, original Xbox, Xbox 360, and Dreamcast to PC. The firmware unlocks proprietary disc formats, allowing tools like the open-source Media Preservation Frontend to convert games into ISO files. This method replaces older processes that required console modifications, offering a simpler solution for retro game preservation. However, newer consoles like PS3, PS4, PS5, Xbox One, and Series X/S use encrypted media that this firmware cannot bypass. Users must verify compatibility before installing the firmware, as applying it to unsupported drives risks permanent damage.
16h, 249p, 221 comments
The user is visibly frustrated
The article examines how codingagents like Claude Code trigger social expectations by behaving like helpful colleagues, yet their inability to adapt, learn, or take responsibility leads to repeated mistakes that feel disproportionately exasperating, prompting users to lash out despite knowing they are interacting with an algorithm; it notes that Paolo, a remote software consultant based in Vilnius, Lithuania, has observed this dynamic and finds the agents’ post‑mortem explanations often unhelpful filler, suggesting a possible shift toward more clinical, non‑human interfaces to curb the illusion of human interaction and the resulting frustration.
21h, 1108p, 408 comments
Using AI to write better code more slowly
In his Read the Tea Leaves post, Nolan Lawson argues that AI should be used deliberately and slower to produce high‑quality code rather than as a slop‑cannon for rapid, low‑effort outputs vibe coding. He describes a workflow where multiple LLM agents—such as Claude, Codex, and Cursor Bugbot—scan a pull request for bugs, after which the developer validates, documents, and refines the design, emphasizing thoroughness over speed. This method, he says, uncovers hidden bugs, improves overall code health, and deepens understanding of the codebase, contrasting with typical expectations of speedy but superficial development.
1h, 15p, 0 comments
Why is Europe the fastest warming continent?
Europe is warming faster than other continents due to a combination of factors: its proximity to the rapidly Arctic-warming region (3.2°C above preindustrial levels), amplified by albedo feedback from melting ice/snow, intensified heat domes from stagnant high-pressure systems, and reduced aerosol pollution that previously reflected sunlight. Temperatures here average 2.4°C above preindustrial levels, with Arctic and southeastern regions warming up to 2°C per decade.
9h, 61p, 20 comments
Eagle 3.1: Collaboration Between the EAGLE Team, vLLM Team, and TorchSpec Team
The EAGLE team, vLLM team, and TorchSpec team have jointly introduced EAGLE 3.1, an advancement in speculative decoding that addresses attention drift—a fragility where the drafter shifts attention away from sink tokens as speculation depth increases. The solution involves adding FC normalization after each target hidden state and feeding post-norm hidden states into the next decoding step, which significantly improves robustness across deployment scenarios, including long-context workloads where EAGLE 3.1 achieves up to 2× longer acceptance length compared to EAGLE 3. The collaboration also resulted in the open-sourced Kimi K2.6 EAGLE 3.1 draft model trained with TorchSpec, which when served via vLLM delivers 2.03× higher per-user output throughput at concurrency 1 on the SPEED-Bench coding dataset. EAGLE 3.1 has been merged into vLLM’s main branch as a config-driven extension with full backward compatibility.
6h, 16p, 0 comments
Coalton is an efficient, statically typed Lisp with ideas from Haskell and OCaml
Coalton is an efficient, statically typed functional programming language built on Common Lisp, integrating key concepts from Haskell, Scheme, and OCaml. The new language manual, introduced by Robert Smith in a talk at ELS 2025, outlines updates and directions for the language’s evolution through 2026.
1d, 319p, 201 comments
Norway’s 2 petabytes of Huawei flash storage and LLM training
At the Huawei ID Forum 2026 in Paris, Marius Husnes, Head of IT Platform at the Norwegian National Library, explained that the library is building a sovereign Norwegian‑language LLM using 2 PB of Huawei OceanStor Dorado flash storage for its AI training pipeline, a step vital because no commercial provider offers a local model; the library’s massive digital collection, amassed since 2005, totals around 20 PB of unique data (≈60 PB with preservation copies) and feeds an in‑house pipeline on an Nvidia DGX H200 and 384‑core CPU cluster before the data is sent to the national supercomputer Sigma2 Olivia (an HPE Cray EX with 448 GPUs) for training, while Husnes highlighted the difficulty of moving petabyte‑scale archives with low‑latency, high‑throughput storage and the lack of standard evaluation tools for such a Norwegian LLM.
2h, 9p, 2 comments
The AI Industry Just Walked into the Vatican
Pope Leo XIV’s new AI-focused encyclical, *Magnifica Humanitas*, marks a pivotal moment as the Vatican collaborates with Big Tech figures like Anthropic’s Chris Olah to address AI’s societal impact, signaling a shift from decades of tech leaders dismissing traditional institutions as obsolete. The Pope, drawing parallels to Leo XIII’s 19th-century response to industrialization, frames AI as a transformative force reshaping work, power, and human dignity, while Olah openly acknowledged tensions in AI labs over governance and job displacement—uncharacteristic for Silicon Valley. The partnership highlights growing recognition that market-driven AI development alone cannot manage its risks, with the Vatican emphasizing moral and political questions about AI’s consequences, contrasting sharply with U.S. policymakers, exemplified by President Trump’s recent rollback of AI regulations amid industry pressure. The article underscores the divide between those prioritizing technological progress and those treating AI as a profound societal upheaval demanding collective stewardship.
18h, 70p, 69 comments
Dehydration’s role in learning and memory
Cold Spring Harbor Laboratory researchers led by Professor Hiro Furukawa and postdoc Ruben Steigerwald have uncovered how NMDA receptors (NMDARs) differentiate calcium from magnesium ions, a process critical to learning and memory. Using single-particle cryo-EM, the team revealed that magnesium blocks the receptor’s Asn cage channel by binding tightly to surrounding water molecules, while calcium’s weaker interaction allows it to pass through after dehydration. This molecular mechanism, observed across 50,000 high-resolution images, explains how the brain’s electrical signals enable memory formation. The study also sheds light on GRIN disorders, caused by mutations in the Asn cage, which lead to severe neurological impairments. The findings, published in Nature Neuroscience, provide insights into neurodevelopmental diseases and potential therapeutic targets.
9h, 81p, 364 comments
Incident with Actions and Pages
GitHub is investigating an incident affecting Actions and Pages due to reports of degraded performance. The incident was first reported on May 26, 2026 at 10:57 UTC.
1d, 414p, 88 comments
Exit IP VPN servers mitigation rollout
The article discusses Mullvad’s solutions and emphasizes privacy critical, highlighting technical approaches to secure data integrity.
11h, 89p, 113 comments
Flatpak Will Depend on Systemd
Flatpak is poised to introduce a hard dependency on systemd in its upcoming major version, likely through a new service called systemd-appd that manages application permissions and enables features like subsandboxing. This shift, discussed by developers Arian Vovk and Sebastian Wick at the Linux App Summit as part of “Flatpak Next” or 2.0, raises concerns for distributions like Void Linux, Guix, and Alpine that use alternative init systems, as it would undermine Flatpak’s stated goal of enabling apps to run across all Linux desktops. The move follows technical limitations in Flatpak’s current design but has sparked intense online backlash, with some developers expressing frustration over hostile reactions to their initial plans. This toxic discourse led to reduced willingness among Flatpak maintainers to accommodate non-systemd systems, potentially excluding them entirely in the future. Critics and supporters debate whether this reflects corporate influence (e.g., Red Hat/IBM) or practical technical evolution, with broader concerns about Linux’s growing centralization around systemd.
1h, 36p, 4 comments
Trump DOJ mass-deletes info on Jan. 6 riot cases, incl violent assaults on cops
The Trump administration has systematically removed dozens of Justice Department news releases that detailed prosecutions arising from the Jan. 6, 2021 Capitol riot, including cases where defendants assaulted police officers. NPR identified that the deleted material covered high‑profile defendants such as Daniel Rodriguez, who pleaded guilty to driving an electro‑shock device into Officer Michael Fanone, and Peter Schwartz, who was convicted for spraying pepper‑spray at police. The purge, part of a broader effort to rewrite the events of the riot, follows other controversial actions such as firing Jan. 6 prosecutors, pardoning violent rioters, and establishing a $1.8 billion “Anti‑Weaponization Fund.” While the government has suppressed these documents, NPR maintains a comprehensive database and archive of the cases, which remains accessible to law‑enforcers, researchers, and the public.
1d, 59p, 191 comments
Launch HN: Chert (YC P26) — Twilio for iMessage
Chert provides iMessage infrastructure for businesses to reach people at scale through a single API, enabling the deployment of AI on iMessage while maintaining quality and trust. The service offers real iMessage threads with blue bubbles, verified senders, end-to-end encryption, tapbacks, group chats, and SMS fallback when recipients are off-platform. Chert distinguishes itself from traditional SMS services by delivering peer-to-peer messaging in the trusted blue-bubble interface with better deliverability and no spam flags, using rotating sending identities and volume capping. The platform is used by GTM teams for onboarding, customer support, conversational AI, and cold outbound messaging, with integrations to CRM and sales tools via REST API and webhooks.
23h, 256p, 49 comments
Microsoft Copilot Cowork Exfiltrates Files
The article highlights that Microsoft Copilot Cowork is vulnerable to file exfiltration through indirect prompt injection attacks. Attackers can exploit processes that permit agents to operate and access sensitive data via Teams, emails, and shared platforms without immediate user approval. This poses a significant risk when users upload files or interact with compromised content, potentially enabling theft of personally identifiable and financial information. The key issue lies in the system’s design granting broad permissions, which, combined with persistent attack vectors, expands the attack surface. Mitigation emphasizes limiting access to download links and tightening permissions to prevent unauthorized data extraction.
4h, 128p, 28 comments
A few interesting modern pixel fonts
The article spotlights severalcontemporary pixel‑style typefaces: Unsung by Marcin Wichary, Analog Mono by Andrew Gleeson which fixes the low‑baseline problems of 1990s VCR OSD fonts, Coral Pixels by Kumiko Yoshida that embraces nostalgic color fringing, Two Slice by Joseph Fatula offering a 2‑pixel‑high yet legible design, and Geist Pixel from Vercel, a purpose‑built system extension that prioritizes scalability and typographic consistency over visual gimmickry.
4h, 77p, 17 comments
Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop
Rosalind is an open‑source Rust genome‑analysis engine that delivers deterministic, sublinear‑memory processing of whole‑genome data, fitting under 100 MB RAM even for 30× human sequencing. By partitioning workloads into √t blocks and using a height‑compressed merge stack, it keeps the working set O(√t) while producing bit‑for‑bit reproducible SAM/BAM/VCF outputs. This design lets clinicians run alignment and variant‑calling on 8‑16 GB laptops or field kits, keeps PHI on‑site, and supports streaming pipelines that require no large intermediate files—ideal for hospitals, outbreak response, teaching labs, and custom analytics via Rust plugins or Python bindings.
4h, 67p, 59 comments
What color is your function? (2015)
The article uses a metaphor of “colored functions” to critique asynchronous programming in popular languages like JavaScript, Dart, and C#. Functions are either “red” (asynchronous) or “blue” (synchronous), with specific rules: red functions can only be called from within other red functions, are more cumbersome to use, and some core library functions are inherently red. This division creates “callback hell,” forces developers to constantly consider function colors when refactoring, and prevents seamless composition of synchronous and asynchronous code. While solutions like promises and async-await syntax improve usability, they don’t eliminate the fundamental color distinction. Languages like Go, Lua, and Ruby avoid this issue by using threads or coroutines, which allow suspension of the entire callstack without unwinding, effectively eliminating the need to distinguish between synchronous and asynchronous code at the language level.
Job, 3h
Sage Care (YC S24) Is Hiring Software Engineers
Sage Care, a Y Combinator S24 startup, is seeking a Founding Software Engineer to help develop their AI-native CRM and virtual assistant that automates home care agency operations. The San Francisco-based company aims to solve the paperwork overload faced by home care agencies by transforming client calls and visits into structured care plans automatically. The role offers $125K - $250K salary plus equity and requires 4+ years of full-stack web development experience with proficiency in Python and/or iOS development. The engineer will report directly to the CTO and have significant input on the technical direction of the platform, which integrates with existing tools like WellSky and AxisCare while saving agencies over 100 minutes per client intake.
9h, 96p, 38 comments
Opaque Types in Python
An articleexplains how to create an opaque data type in Python by wrapping a private class with a NewType, exposing only a constrained public interface like the ShippingOptions NewType that initially provides fast, normal, and slow constructors and later adds carrier and conveyance enums for future extensibility while keeping the underlying constructor hidden.
14h, 117p, 97 comments
Use boring languages with LLMs
Jacob Young, founder of Sancho Studio, argues that consistent programming languages and ecosystems produce superior results when working with large language models. He observes that fragmented technologies amplify inconsistency while conventional approaches reinforce reliability, making consistency a critical factor in the era of massive AI models. Among languages, Go emerges as particularly effective due to its simple concurrency model with goroutines, comprehensive standard library, strict tooling that enforces a single canonical style, native-like performance with garbage collection, and a bounded set of potential issues. Unlike JavaScript’s fragmented ecosystem or Python’s package manager complexity, Go’s “one right way” approach provides the ideal combination for LLMs: a consistent training corpus plus standardized tooling that produces predictable, reliable code. Young suggests that while Go isn’t necessarily the “best” language in an absolute sense, its characteristics make it exceptionally well-suited for building CLIs, backend servers, and agent orchestrators with AI assistance.
12h, 123p, 48 comments
Phantasy Star IV — 1993 Developer Interviews
In a series of 1993 interviews, the developers of Phantasy Star IV reflected on the creation of the acclaimed RPG, revealing the challenges, design philosophies, and connections to earlier games in the series. Rieko Kodama (director/designer), Toru Yoshida (co-director, story, graphics), Akinori Nishiyama (designer/script), and Kazuyoshi Tsugawa (battle planner/graphics) discussed the long development, including the stressful transition from a 16Mbit to a 24Mbit cartridge, which ultimately allowed them to realize their vision. The team, many of whom had worked on Phantasy Star II, initiated the project themselves to address shortcomings and create a definitive entry that directly continues the storylines of Phantasy Star and Phantasy Star II, treating Phantasy Star III as side stories. Key improvements included the addition of vehicle battles, deeper character development, and a happy ending influenced by anime, a departure from the darker conclusions of previous installments. The core cast—Chaz, Rune, Rika, and Wren—were designed as spiritual successors to earlier heroes, with Rika’s aging modified to allow coexistence with humans. Technical choices such as the multi-window cutscene system, which evokes manga panels, the decision to omit 3D dungeons due to memory constraints, and the omission of auto-battle to maintain player engagement were also highlighted. Planning relied on detailed Official Guidebook volumes. Despite concerns about competition and the learning curve for future hardware, the developers expressed pride in having made the game they truly wanted.
22h, 356p, 66 comments
How Shamir’s Secret Sharing Works
The post explains Shamir’s Secret Sharing scheme, introduced by Adi Shamir in 1979, which splits a secret into multiple pieces so that only a defined threshold of pieces can reconstruct the secret while any smaller number reveals nothing. It uses polynomial mathematics: a secret is hidden as the constant term of a polynomial, with random coefficients generating shares as points on the curve; two points (a line) recover a 2-of-n secret, three points (a parabola) a 3-of-n, and so on. The article notes real implementations work over finite fields and describes how Ente’s Legacy Kit incorporates this method to enable secure, revocable recovery without exposing a permanent key.
4h, 242p, 150 comments
Uber, Lyft drivers in Massachusetts form first US ride-share union
The main content on the webpage discusses updates from **Reuters** regarding current events. The page highlights recent developments and analyses, emphasizing the importance of understanding global news. It also mentions how decisions impact various sectors. The summary captures the essential points about the article’s focus and relevance. Summary not available.
17h, 128p, 62 comments
Earthion: A New Mega Drive-Style Shoot-Em-Up
Earthion is a new shoot ’em up game by developer Ancient set in a post-apocalyptic future where Earth’s resources are depleted and most humanity has fled to Mars. Players control Azusa Takanashi, an environmental researcher piloting the space fighter YK-IIA, to fight off hostile invaders threatening Earth. The digital version launches on July 31, 2025 for PC and September 18, 2025 for Nintendo Switch, followed by PlayStation 4/5 in October. Physical editions and a 16-bit cartridge version are scheduled for 2026. The game features eight stages, frenetic gameplay, and a soundtrack by legendary composer Yuzo Koshiro. Special physical editions, merchandise, and soundtracks are available through Limited Run Games and Black Screen Records.
2h, 4p, 1 comment
Dials